Potassium Carbonate → HCID 66652495, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-chloro-N-(ethoxymethyl)-2,4-difluoro-N-(5-fluoropyrimidin-2-yl)benzenesulfonamide (Preparation 14, 75 mg, 0.20 mmol) in dimethylsulfoxide (1 mL) was added 2-(2-aminopyridin-4-yl)-4-chlorophenol (Preparation 13, 43.3 mg, 0.20 mmol) and potassium carbonate (40.7 mg, 0.30 mmol). The reaction mixture was stirred at 50° C. for 19 hours, then diluted with ethyl acetate (30 mL) and washed with 1N aqueous sodium hydroxide solution, water and brine, dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography (50% hexanes in ethyl acetate to 100% ethyl acetate gradient elution) to afford the title compound as a white solid (68 mg).

Provenance & Evidence