Dimethylformamide dimethyl acetal → (2E)-3-(dimethylamino)-1-[2-hydroxy-5-(trifluoromethyl)phenyl]prop-2-en-1-one

Participants

Reaction Conditions

Reaction Steps

1-[2-Hydroxy-5-(trifluoromethyl)phenyl]ethanone, (Preparation 32, 7.0 g, 0.034 mol) was taken in dimethylformamide dimethylacetal (18.2 mL, 0.14 mol) at ambient temperature and then heated at 110° C. for 30 minutes. The reaction mixture was concentrated in vacuo and the crude product was crystallised from 2-propanol to afford the title compound as bright yellow solid (6.4 g, 73%). 1HNMR (CDCl3): δ 3.02 (s, 3H) 3.22 (s, 3H), 5.72 (d, 1H), 6.99 (d, 1H), 7.55 (d 1H), 7.89-7.94 (m, 2H), 14.45 (s, 1H).

Provenance & Evidence