HCID 66655388, compound → N-(2,4-dimethoxybenzyl)-3-iodo-4-[2-pyridazin-4-yl-4-(trifluoromethyl)phenoxy]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide

HRID 2283652Notes

Reaction equation

HRID 2283652 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:10]=[CH:9][C:8]=2[OH:17])=[CH:3][N:2]=1.[CH3:18][O:19][C:20]1[CH:43]=[C:42]([O:44][CH3:45])[CH:41]=[CH:40][C:21]=1[CH2:22][N:23]([C:35]1[S:39][N:38]=[CH:37][N:36]=1)[S:24]([C:27]1[CH:32]=[C:31]([I:33])[C:30](F)=[CH:29][CH:28]=1)(=[O:26])=[O:25]>>[CH3:18][O:19][C:20]1[CH:43]=[C:42]([O:44][CH3:45])[CH:41]=[CH:40][C:21]=1[CH2:22][N:23]([C:35]1[S:39][N:38]=[CH:37][N:36]=1)[S:24]([C:27]1[CH:28]=[CH:29][C:30]([O:17][C:8]2[CH:9]=[CH:10][C:11]([C:13]([F:15])([F:16])[F:14])=[CH:12][C:7]=2[C:4]2[CH:5]=[CH:6][N:1]=[N:2][CH:3]=2)=[C:31]([I:33])[CH:32]=1)(=[O:25])=[O:26]

Participants

3

Reactant 2

HCID 66655388HCID 66655388, compoundHCID 1357416972-(Pyridazin-4-yl)-4-(trifluoromethyl)phenol

Product 1

HCID 66652980N-(2,4-dimethoxybenzyl)-3-iodo-4-[2-pyridazin-4-yl-4-(trifluoromethyl)phenoxy]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide

Procedure

The title compound was prepared according to Preparation 35 at 60° C. over 4 days using 2-pyridazin-4-yl-4-(trifluoromethyl)phenol (Preparation 30) and N-(2,4-dimethoxybenzyl)-4-fluoro-5-iodo-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide (Preparation 37) to give the product (420 mg, 43%).

Workup

  1. customaccording to Preparation 35 at 60° C. over 4 days

Sources & evidence

ORD record
ord-00d9b3f70b5e4aaa8a68d08a31515845
Source dataset
uspto-grants-2015_09
Patent number
US09145407B2

Reaction notes

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