HCID 90309174, compound → HCID 90308750, compound

Participants

Reaction Steps

10% Palladium-carbon (500 mg) was added to a solution of 1-(1-methyl-1H-pyrazol-3-yl)-4-nitro-1H-indole obtained in the above-described Step 1 (625 mg) in ethyl acetate (20 ml) under nitrogen airflow. Then the reaction solution was stirred under hydrogen atmosphere at room temperature for 2 hours and a half. The insolubles were filtrated with celite, and then the solvent was evaporated under vacuum. The resultant residue was purified by column chromatography on silica gel (developing solvent:hexane-ethyl acetate) to obtain 1-(1-methyl-1H-pyrazol-3-yl)-1H-indol-4-amine.

Provenance & Evidence