Sulfuric Acid → HCID 90308837, compound

HRID 2283693Notes

Reaction equation

HRID 2283693 reaction equation
S(=O)(=O)(O)O.[Br:6][C:7]1[CH:8]=[C:9]([N+:16]([O-:18])=[O:17])[CH:10]=[C:11]2[C:15]=1[NH:14][N:13]=[CH:12]2>CC(O)(C)C>[Br:6][C:7]1[C:15]2[C:11](=[CH:12][N:13]([C:11]([CH3:15])([CH3:12])[CH3:10])[N:14]=2)[CH:10]=[C:9]([N+:16]([O-:18])=[O:17])[CH:8]=1

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 14819687-bromo-5-nitro-1H-indazole

Product 1

HCID 90308837HCID 90308837, compound

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Procedure

2-Methyl-2-propanol (5 mL) and concentrated sulfuric acid (0.1 mL) were added to 7-bromo-5-nitro-1H-indazole (484 mg), and the reaction solution was allowed to react in a microwave reactor at 100° C. for 1 hour. After dilution with ethyl acetate, the reaction solution was washed successively with an aqueous sodium bicarbonate solution and a saturated saline solution. After drying over anhydrous sodium sulfate, the solvent was evaporated under vacuum to obtain 7-bromo-2-(tert-butyl)-5-nitro-2H-indazole as a light yellow solid.

Workup

  1. customto react in a microwave reactor at 100° C. for 1 hour
  2. washAfter dilution with ethyl acetate, the reaction solution was washed successively with an aqueous sodium bicarbonate solution
  3. dry with materialAfter drying over anhydrous sodium sulfate
  4. customthe solvent was evaporated under vacuum

Sources & evidence

ORD record
ord-46a426dcc4f44cf0856cbba3f8dd2206
Source dataset
uspto-grants-2015_09
Patent number
US09145414B2

Reaction notes

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