Water → HCID 90308704, compound

Participants

Reaction Steps

Sodium hydride (60% in oil, 240 mg) and iodoethane (0.64 mL) were added to a solution of 5-bromo-7-methyl-1H-indazole (844 mg) in DMF (10 mL), and the reaction solution was stirred at room temperature for 15 minutes. Water was added to the reaction solution, and then the reaction solution was extracted with ethyl acetate. The organic layer was washed successively with water and a saturated saline solution. After drying over anhydrous sodium sulfate, the solvent was evaporated under vacuum. The resultant residue was purified by column chromatography on silica gel (developing solvent:hexane/ethyl acetate) to obtain 5-bromo-1-ethyl-7-methyl-1H-indazole and 5-bromo-2-ethyl-7-methyl-2H-indazole.

Provenance & Evidence