HCID 24728762, compound → HCID 90308990, compound

HRID 2283707Notes

Reaction equation

HRID 2283707 reaction equation
[CH3:1][C:2]1[CH:10]=[C:9]([N+:11]([O-])=O)[CH:8]=[C:7]2[C:3]=1[CH:4]=[N:5][NH:6]2.[F:14][CH:15]([F:27])N1C=C2C(C=C(N)C=C2C)=N1>>[F:14][CH:15]([F:27])[N:6]1[C:7]2[C:3](=[C:2]([CH3:1])[CH:10]=[C:9]([NH2:11])[CH:8]=2)[CH:4]=[N:5]1

Participants

3

Reactant 2

HCID 24728762HCID 24728762, compoundHCID 90309022HCID 90309022, compound

Product 1

HCID 90308990HCID 90308990, compound

Procedure

In accordance with Example 24 (Steps 1 and 2), 4-methyl-6-nitro-1H-indazole (934 mg) was used instead of 6-nitro-1H-indazole to obtain 1-(difluoromethyl)-4-methyl-1H-indazol-6-amine (112 mg) and 2-(difluoromethyl)-4-methyl-2H-indazol-6-amine.

Sources & evidence

ORD record
ord-9e497cbc7d094ea4b3877cb9d6460bee
Source dataset
uspto-grants-2015_09
Patent number
US09145414B2

Reaction notes

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