6-bromo-4-methoxy-1H-indazole → 6-bromo-1-ethyl-4-methoxy-1H-indazole

HRID 2283715Notes

Reaction equation

HRID 2283715 reaction equation
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][NH:8]2)=[C:4]([O:11][CH3:12])[CH:3]=1.Br[C:14]1C=C(OC)C2C([CH:22]=1)=NN(CC)C=2>>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][N:8]2[CH2:14][CH3:22])=[C:4]([O:11][CH3:12])[CH:3]=1

Participants

3

Reactant 2

HCID 247281116-bromo-4-methoxy-1H-indazoleHCID 903090296-bromo-2-ethyl-4-methoxy-2H-indazole

Product 1

HCID 903090996-bromo-1-ethyl-4-methoxy-1H-indazole

Procedure

In accordance with Example 70 (Step 1), 6-bromo-4-methoxy-1H-indazole (329 mg) was used instead of 5-bromo-7-methyl-1H-indazole to obtain 6-bromo-1-ethyl-4-methoxy-1H-indazole (210 mg) and 6-bromo-2-ethyl-4-methoxy-2H-indazole.

Sources & evidence

ORD record
ord-d2cb228e313a43a39b66d11b75611260
Source dataset
uspto-grants-2015_09
Patent number
US09145414B2

Reaction notes

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