Bromocyclobutane → HCID 90308997, compound

HRID 2283718Notes

Reaction equation

HRID 2283718 reaction equation
[CH3:1][C:2]1[CH:10]=[C:9]([N+:11]([O-])=O)[CH:8]=[C:7]2[C:3]=1[CH:4]=[N:5][NH:6]2.Br[CH:15]1[CH2:18][CH2:17][CH2:16]1>>[CH:15]1([N:6]2[C:7]3[C:3](=[C:2]([CH3:1])[CH:10]=[C:9]([NH2:11])[CH:8]=3)[CH:4]=[N:5]2)[CH2:18][CH2:17][CH2:16]1.[CH:15]1([N:5]2[CH:4]=[C:3]3[C:7]([CH:8]=[C:9]([NH2:11])[CH:10]=[C:2]3[CH3:1])=[N:6]2)[CH2:18][CH2:17][CH2:16]1

Participants

4

Reactant 2

HCID 78110BromocyclobutaneHCID 24728762HCID 24728762, compound

Product 2

HCID 90308997HCID 90308997, compoundHCID 90309105HCID 90309105, compound

Procedure

In accordance with Example 24 (Steps 1 and 2), 4-methyl-6-nitro-1H-indazole was used instead of 6-nitro-1H-indazole, and bromocyclobutane was used instead of chlorodifluoroacetic acid sodium to obtain 1-cyclobutyl-4-methyl-1H-indazol-6-amine and 2-cyclobutyl-4-methyl-2H-indazol-6-amine.

Sources & evidence

ORD record
ord-c1e323527eb142fbb50073f3a754ffa8
Source dataset
uspto-grants-2015_09
Patent number
US09145414B2

Reaction notes

Loading…