Einecs 211-027-4 → HCID 66958727, compound

HRID 2283835Notes

Reaction equation

HRID 2283835 reaction equation
[CH2:1]([N:3]1[C:15]([CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[C:14]2[C:5]([C:6]([NH2:26])=[N:7][C:8]3[CH:9]=[C:10]([O:24]C)[CH:11]=[CH:12][C:13]=32)=[N:4]1)[CH3:2].[Cl-:27].[NH+]1C=CC=CC=1>>[ClH:27].[NH2:26][C:6]1[C:5]2=[N:4][N:3]([CH2:1][CH3:2])[C:15]([CH2:16][CH2:17][C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)=[C:14]2[C:13]2[CH:12]=[CH:11][C:10]([OH:24])=[CH:9][C:8]=2[N:7]=1

Participants

3

Reactant 2

HCID 69401Einecs 211-027-4HCID 57717501HCID 57717501, compound

Product 1

HCID 66958727HCID 66958727, compoundYield 96.3%

Procedure

2-Ethyl-7-methoxy-1-(2-phenylethyl)-2H-pyrazolo[3,4-c]quinolin-4-amine (0.37 g, 1.07 mmol) was added in one portion to boiling pyridinium chloride (3.70 g, 32.0 mmol). The mixture was heated at reflux for 4 hours, and then was allowed to cool to room temperature. The mixture was triturated with ice water and the precipitate was isolated by filtration, washed with water, and dried to yield 0.38 g of 4-amino-2-ethyl-1-(2-phenylethyl)-2H-pyrazolo[3,4-c]quinolin-7-ol hydrochloride as a light grey solid, mp>300° C.

Workup

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 4 hours
  3. customThe mixture was triturated with ice water
  4. customthe precipitate was isolated by filtration
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-18db397a2f9744bb86d9870fd5abc3ab
Source dataset
uspto-grants-2015_09
Patent number
US09145410B2

Reaction notes

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