Sodium Hydroxide → 5-(3-benzenesulfonylpropyl)-1-butyl-1H-pyrazole-3-carboxylic acid

HRID 2283870Notes

Reaction equation

HRID 2283870 reaction equation
[OH-].[Na+].[C:3]1([S:9]([CH2:12][CH2:13][CH2:14][C:15]2[N:19]([CH2:20][CH2:21][CH2:22][CH3:23])[N:18]=[C:17]([C:24]([O:26]CC)=[O:25])[CH:16]=2)(=[O:11])=[O:10])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>C(O)C>[C:3]1([S:9]([CH2:12][CH2:13][CH2:14][C:15]2[N:19]([CH2:20][CH2:21][CH2:22][CH3:23])[N:18]=[C:17]([C:24]([OH:26])=[O:25])[CH:16]=2)(=[O:11])=[O:10])[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66959126ethyl 5-(3-benzenesulfonylpropyl)-1-butyl-1H-pyrazole-3-carboxylate

Product 1

HCID 669583705-(3-benzenesulfonylpropyl)-1-butyl-1H-pyrazole-3-carboxylic acidYield 85.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Sodium hydroxide (12 mL, 6M) was added to a solution of ethyl 5-(3-benzenesulfonylpropyl)-1-butyl-1H-pyrazole-3-carboxylate (13.3 g, 35.1 mmol) in 100 mL of ethanol and heated to reflux overnight. The reaction mixture was concentrated under reduced pressure and the residue was diluted with 100 mL of water. The aqueous layer was extracted with several portions of ethyl acetate. The pH of the aqueous layer was adjusted to approximately 2-3 with aqueous hydrochloric acid and was then extracted with several portions of ethyl acetate. The combined organic layers originating from extraction of the aqueous layer were washed with brine, dried over magnesium sulfate, filtered, and concentrated to afford 10.5 g of 5-(3-benzenesulfonylpropyl)-1-butyl-1H-pyrazole-3-carboxylic acid.

Workup

  1. temperatureheated
  2. temperatureto reflux overnight
  3. concentrationThe reaction mixture was concentrated under reduced pressure
  4. additionthe residue was diluted with 100 mL of water
  5. extractionThe aqueous layer was extracted with several portions of ethyl acetate
  6. extractionwas then extracted with several portions of ethyl acetate
  7. extractionThe combined organic layers originating from extraction of the aqueous layer
  8. washwere washed with brine
  9. dry with materialdried over magnesium sulfate
  10. filtrationfiltered
  11. concentrationconcentrated

Sources & evidence

ORD record
ord-8a8334e3385048abbcc1bba0298a8ef1
Source dataset
uspto-grants-2015_09
Patent number
US09145410B2

Reaction notes

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