5-Bromo-6-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-4-ylamine → 5-Bromo-6-{4-[5-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-4-ylamine

HRID 2283951Notes

Reaction equation

HRID 2283951 reaction equation
[Br:1][C:2]1[C:3]([NH2:31])=[N:4][CH:5]=[N:6][C:7]=1[N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[N:15]([CH3:30])[CH:16]=[C:17](C3C=CC(F)=C(C(F)(F)F)C=3)[N:18]=2)[CH2:10][CH2:9]1.[F:32][C:33]1[CH:38]=[CH:37][C:36](C2N(C)C(C3CCNCC3)=NC=2)=[CH:35][C:34]=1[C:51]([F:54])([F:53])[F:52]>>[Br:1][C:2]1[C:3]([NH2:31])=[N:4][CH:5]=[N:6][C:7]=1[N:8]1[CH2:9][CH2:10][CH:11]([C:14]2[N:15]([CH3:30])[C:16]([C:36]3[CH:37]=[CH:38][C:33]([F:32])=[C:34]([C:51]([F:54])([F:53])[F:52])[CH:35]=3)=[CH:17][N:18]=2)[CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 894425615-Bromo-6-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-4-ylamineHCID 894427924-[5-(4-Fluoro-3-trifluoromethyl-phenyl)-1-methyl-1h-imidazol-2-yl]-piperidine

Product 1

HCID 894455035-Bromo-6-{4-[5-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-4-ylamine

Procedure

The title compound was prepared in an analogous manner as 5-Bromo-6-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-4-ylamine using 4-[5-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1h-imidazol-2-yl]-piperidine instead of 4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1h-imidazol-2-yl]-piperidine. LC-MS: (M+1=499, obsd.=499).

Sources & evidence

ORD record
ord-d4a0f6ae028f4844a3af8f96b4d7dbe2
Source dataset
uspto-grants-2015_09
Patent number
US09145392B2

Reaction notes

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