5-Bromo-6-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-4-ylamine → HCID 178508806, compound

HRID 2283952Notes

Reaction equation

HRID 2283952 reaction equation
[Br:1][C:2]1[C:3]([NH2:31])=[N:4][CH:5]=[N:6][C:7]=1[N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[N:15](C)[CH:16]=[C:17]([C:19]3[CH:24]=[CH:23][C:22](F)=[C:21]([C:26]([F:29])([F:28])[F:27])[CH:20]=3)[N:18]=2)[CH2:10][CH2:9]1.FC(F)(F)C1C=C(C2N=C(C3CCNCC3)NC=2)C=CC=1>>[Br:1][C:2]1[C:3]([NH2:31])=[N:4][CH:5]=[N:6][C:7]=1[N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[NH:15][CH:16]=[C:17]([C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([C:26]([F:29])([F:28])[F:27])[CH:20]=3)[N:18]=2)[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 894425615-Bromo-6-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-4-ylamineHCID 178506150HCID 178506150, compound

Product 1

HCID 178508806HCID 178508806, compound

Procedure

The title compound was prepared in an analogous manner as 5-Bromo-6-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-4-ylamine using 4-[4-(3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-piperidine instead of 4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1h-imidazol-2-yl]-piperidine. LC-MS: (M+1=467, obsd.=467).

Sources & evidence

ORD record
ord-b30349584c694b87a9fb0a694ae2738b
Source dataset
uspto-grants-2015_09
Patent number
US09145392B2

Reaction notes

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