5-Bromo-4-chloropyrimidine → HCID 178506149, compound

HRID 2283953Notes

Reaction equation

HRID 2283953 reaction equation
[Br:1][C:2]1[C:3](N)=[N:4][CH:5]=[N:6][C:7]=1[N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[NH:15][CH:16]=[C:17]([C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:28])([F:27])[F:26])[CH:20]=3)[N:18]=2)[CH2:10][CH2:9]1.BrC1C(Cl)=NC=NC=1>>[Br:1][C:2]1[C:7]([N:8]2[CH2:9][CH2:10][CH:11]([C:14]3[NH:15][CH:16]=[C:17]([C:19]4[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:27])([F:26])[F:28])[CH:20]=4)[N:18]=3)[CH2:12][CH2:13]2)=[N:6][CH:5]=[N:4][CH:3]=1

Participants

3

Reactant 2

HCID 122700785-Bromo-4-chloropyrimidineHCID 178508806HCID 178508806, compound

Product 1

HCID 178506149HCID 178506149, compound

Procedure

The title compound was prepared in an analogous manner as 5-Bromo-6-{4-[4-(3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-4-ylamine using 5-bromo-4-chloropyrimidine instead of 5-bromo-6-chloropyrimidin-4-amine. LC-MS: (M+1=452, obsd.=452).

Sources & evidence

ORD record
ord-dc7e89367e14428fb8c6e71fb10a8acf
Source dataset
uspto-grants-2015_09
Patent number
US09145392B2

Reaction notes

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