4-Amino-6-chloropyrimidine-5-carbonitrile → 4-Amino-6-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidine-5-carbonitrile

HRID 2283956Notes

Reaction equation

HRID 2283956 reaction equation
[NH2:1][C:2]1[C:7]([CH:8]=O)=[C:6]([N:10]2[CH2:15][CH2:14][CH:13]([C:16]3[N:17]([CH3:32])[CH:18]=[C:19]([C:21]4[CH:26]=[CH:25][C:24]([F:27])=[C:23]([C:28]([F:31])([F:30])[F:29])[CH:22]=4)[N:20]=3)[CH2:12][CH2:11]2)[N:5]=[CH:4][N:3]=1.[NH2:33]C1C(C#N)=C(Cl)N=CN=1>>[NH2:1][C:2]1[C:7]([C:8]#[N:33])=[C:6]([N:10]2[CH2:15][CH2:14][CH:13]([C:16]3[N:17]([CH3:32])[CH:18]=[C:19]([C:21]4[CH:26]=[CH:25][C:24]([F:27])=[C:23]([C:28]([F:31])([F:30])[F:29])[CH:22]=4)[N:20]=3)[CH2:12][CH2:11]2)[N:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 122782624-Amino-6-chloropyrimidine-5-carbonitrileHCID 894427184-amino-6-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)pyrimidine-5-carbaldehyde

Product 1

HCID 894424644-Amino-6-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidine-5-carbonitrile

Procedure

The title compound was prepared in an analogous manner as 4-Amino-6-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidine-5-carbaldehyde using 4-amino-6-chloropyrimidine-5-carbonitrile instead of 4-amino-6-chloropyrimidine-5-carbaldehyde. LC-MS: (M+1=446, obsd.=446).

Sources & evidence

ORD record
ord-fbd3661de7aa4d15bdd60b483beee5be
Source dataset
uspto-grants-2015_09
Patent number
US09145392B2

Reaction notes

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