Potassium Carbonate → 6-{4-[4-(4-Fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-5-methoxy-pyrimidin-4-ylamine

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1h-imidazol-2-yl]-piperidine (40.00 mg; 0.12 mmol; 1.0 eq.), 6-chloro-5-methoxypyrimidin-4-amine (20.48 mg; 0.13 mmol; 1.05 eq.), potassium carbonate (33.78 mg; 0.24 mmol; 2.0 eq.) in DMSO (1.00 ml) in a microwave vial was heated at 150° C. for 2 h. LC-MS show ˜40% conversion and product eluted closely to the amine starting material. The reaction mixture was workup and the crude was purified by reverse phase pre-HPLC (Waters, acetonitrile/0.1% TFA in water) to yield desired product in 22% yield. LC-MS: (M+1=451, obsd.=451).

Provenance & Evidence