4-(Hydroxymethyl)benzeneboronic acid pinacol ester → [4-(4-Amino-6-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-5-yl)-phenyl]-methanol

Participants

Role	Name	HCID	Charge
Reactant	4-(Hydroxymethyl)benzeneboronic acid pinacol ester	HCID 11402050	—
Reactant	5-(4-Fluoro-phenyl)-6-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-4-ylamine	HCID 89442482	—
Product	[4-(4-Amino-6-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-5-yl)-phenyl]-methanol	HCID 89450263	—

Reaction Steps

The title compound was prepared in an analogous manner as 5-(4-Fluoro-phenyl)-6-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-4-ylamine using 4-(hydroxymethyl)benzeneboronic acid pinacol ester instead of 4-fluorophenylboronic acid. LC-MS: (M+1=527, obsd.=527).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09145392B2
Source dataset	uspto-grants-2015_09
ORD ID	ord-d699a0f550204ab4a866c93e7893e550
Source note	uspto-grants-2015_09