Phenylboronic Acid → 6-{4-[4-(4-Fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-5-phenyl-pyrimidin-4-ylamine

Participants

Role	Name	HCID	Charge
Reactant	Phenylboronic Acid	HCID 66827	—
Reactant	5-(4-Fluoro-phenyl)-6-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-4-ylamine	HCID 89442482	—
Product	6-{4-[4-(4-Fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-5-phenyl-pyrimidin-4-ylamine	HCID 89445436	—

Reaction Steps

The title compound was prepared in an analogous manner as 5-(4-Fluoro-phenyl)-6-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-4-ylamine using phenylboronic acid instead of 4-fluorophenylboronic acid. LC-MS: (M+1=497, obsd.=497).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09145392B2
Source dataset	uspto-grants-2015_09
ORD ID	ord-f26bbf870ad348bb9454361a0c021b99
Source note	uspto-grants-2015_09