6-{4-[4-(4-Fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-5-(4-methoxy-phenyl)-pyrimidin-4-ylamine → HCID 178488797, compound

HRID 2283978Notes

Reaction equation

HRID 2283978 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([CH:14]3[CH2:19][CH2:18][N:17]([C:20]4[N:25]=[CH:24][N:23]=[C:22]([NH2:26])[C:21]=4[C:27]4[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=4)[CH2:16][CH2:15]3)[N:11](C)[CH:12]=2)=[CH:4][C:3]=1[C:35]([F:38])([F:37])[F:36].BrC1C(N)=NC=NC=1N1CCC(C2NC=C(C3C=CC=C(C(F)(F)F)C=3)N=2)CC1>>[CH3:34][O:33][C:30]1[CH:31]=[CH:32][C:27]([C:21]2[C:22]([NH2:26])=[N:23][CH:24]=[N:25][C:20]=2[N:17]2[CH2:16][CH2:15][CH:14]([C:10]3[NH:11][CH:12]=[C:8]([C:5]4[CH:6]=[CH:7][CH:2]=[C:3]([C:35]([F:38])([F:37])[F:36])[CH:4]=4)[N:9]=3)[CH2:19][CH2:18]2)=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 894427756-{4-[4-(4-Fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-5-(4-methoxy-phenyl)-pyrimidin-4-ylamineHCID 178508806HCID 178508806, compound

Product 1

HCID 178488797HCID 178488797, compound

Procedure

The title compound was prepared in an analogous manner as 6-{4-[4-(4-Fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-5-(4-methoxy-phenyl)-pyrimidin-4-ylamine using 5-Bromo-6-{4-[4-(3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-4-ylamine instead of 5-bromo-6-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)pyrimidin-4-amine. LC-MS: (M+1=495, obsd.=495).

Sources & evidence

ORD record
ord-3ab524562fb6488785fe16460a783db9
Source dataset
uspto-grants-2015_09
Patent number
US09145392B2

Reaction notes

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