6-{4-[4-(4-Fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-5-(4-methoxy-phenyl)-pyrimidin-4-ylamine → HCID 178488763, compound

HRID 2283979Notes

Reaction equation

HRID 2283979 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([CH:14]3[CH2:19][CH2:18][N:17]([C:20]4[N:25]=[CH:24][N:23]=[C:22](N)[C:21]=4[C:27]4[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=4)[CH2:16][CH2:15]3)[N:11](C)[CH:12]=2)=[CH:4][C:3]=1[C:35]([F:38])([F:37])[F:36].BrC1C(N2CCC(C3NC=C(C4C=CC=C(C(F)(F)F)C=4)N=3)CC2)=NC=NC=1>>[CH3:34][O:33][C:30]1[CH:31]=[CH:32][C:27]([C:21]2[C:20]([N:17]3[CH2:16][CH2:15][CH:14]([C:10]4[NH:11][CH:12]=[C:8]([C:5]5[CH:6]=[CH:7][CH:2]=[C:3]([C:35]([F:38])([F:36])[F:37])[CH:4]=5)[N:9]=4)[CH2:19][CH2:18]3)=[N:25][CH:24]=[N:23][CH:22]=2)=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 894427756-{4-[4-(4-Fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-5-(4-methoxy-phenyl)-pyrimidin-4-ylamineHCID 178506149HCID 178506149, compound

Product 1

HCID 178488763HCID 178488763, compound

Procedure

The title compound was prepared in an analogous manner as 6-{4-[4-(4-Fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-5-(4-methoxy-phenyl)-pyrimidin-4-ylamine using 5-Bromo-4-{4-[4-(3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidine instead of 5-bromo-6-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)pyrimidin-4-amine. LC-MS: (M+1=480, obsd.=480).

Sources & evidence

ORD record
ord-4221a952b91f491488a64b2433a3bcbd
Source dataset
uspto-grants-2015_09
Patent number
US09145392B2

Reaction notes

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