Sodium borohydride → (4-Amino-6-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-5-yl)-methanol

Participants

Reaction Steps

The reaction mixture of 4-amino-6-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)pyrimidine-5-carbaldehyde (23.00 mg; 0.05 mmol; 1.0 eq.) and sodium borohydride (7.8 mg; 0.21 mmol; 4.0 eq.) in EtOH (2.00 ml) was stirred at room temperature over weekend. The reaction mixture was workup and purified by reverse phase chromatography (Yamazen, acetonitrile/0.1% NH4OH in water). The pure fractions were lyophilized to afford the title compound in 65% yield. LC-MS: (M+1=451, obsd.=451).

Provenance & Evidence