5-(4-Fluoro-phenyl)-6-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-4-ylamine → HCID 89445370, compound

HRID 2283984Notes

Reaction equation

HRID 2283984 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9](N)=[N:10][CH:11]=[N:12][C:13]=2[N:14]2[CH2:19][CH2:18][CH:17]([C:20]3[N:21]([CH3:36])[CH:22]=[C:23]([C:25]4[CH:30]=[CH:29][C:28]([F:31])=[C:27]([C:32]([F:35])([F:34])[F:33])[CH:26]=4)[N:24]=3)[CH2:16][CH2:15]2)=[CH:4][CH:3]=1.BrC1C(N2CCC(C3N(C)C=C(C4C=CC(F)=C(C(F)(F)F)C=4)N=3)CC2)=NC=NC=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:13]([N:14]3[CH2:15][CH2:16][CH:17]([C:20]4[N:21]([CH3:36])[CH:22]=[C:23]([C:25]5[CH:30]=[CH:29][C:28]([F:31])=[C:27]([C:32]([F:33])([F:34])[F:35])[CH:26]=5)[N:24]=4)[CH2:18][CH2:19]3)=[N:12][CH:11]=[N:10][CH:9]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 894424825-(4-Fluoro-phenyl)-6-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-4-ylamineHCID 89442843HCID 89442843, compound

Product 1

HCID 89445370HCID 89445370, compound

Procedure

The title compound was prepared in an analogous manner as 5-(4-Fluoro-phenyl)-6-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-4-ylamine using 5-bromo-4-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidine instead of 5-Bromo-6-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-4-ylamine. LC-MS: (M+1=500, obsd.=500).

Sources & evidence

ORD record
ord-74c24afaadc3475fac3b57835782973c
Source dataset
uspto-grants-2015_09
Patent number
US09145392B2

Reaction notes

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