HCID 178505530, compound → HCID 178508807, compound

HRID 2283985Notes

Reaction equation

HRID 2283985 reaction equation
[Br:1][C:2]1[C:3]([NH2:29])=[N:4][CH:5]=[N:6][C:7]=1[N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[NH:15][CH:16]=[C:17]([C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:28])([F:27])[F:26])[CH:20]=3)[N:18]=2)[CH2:10][CH2:9]1.[F:30]C1C=CC(C2N=C(C3CCNCC3)NC=2)=CC=1C(F)(F)F>>[Br:1][C:2]1[C:3]([NH2:29])=[N:4][CH:5]=[N:6][C:7]=1[N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[NH:15][CH:16]=[C:17]([C:19]3[CH:24]=[CH:23][C:22]([F:30])=[C:21]([C:25]([F:28])([F:27])[F:26])[CH:20]=3)[N:18]=2)[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 178505530HCID 178505530, compoundHCID 178508806HCID 178508806, compound

Product 1

HCID 178508807HCID 178508807, compound

Procedure

The title compound was prepared in an analogous manner as 5-bromo-6-{4-[4-(3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-4-ylamine using 4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1H-imidazol-2-yl}piperidine instead of 4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1h-imidazol-2-yl]-piperidine. LC-MS: (M+1=485, obsd.=485).

Sources & evidence

ORD record
ord-166568a29c964cb7bb4695b7cd485514
Source dataset
uspto-grants-2015_09
Patent number
US09145392B2

Reaction notes

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