2-Ethenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane → 6-{4-[1-(2-Dimethylamino-ethyl)-4-(4-fluoro-3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-piperidin-1-yl}-5-vinyl-pyrimidin-4-ylamine

Participants

Role	Name	HCID	Charge
Reactant	2-Ethenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane	HCID 5233012	—
Reactant	6-(4-(1-(2-(dimethylamino)ethyl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidin-1-yl)-5-(4-fluorophenyl)pyrimidin-4-amine	HCID 89442484	—
Product	6-{4-[1-(2-Dimethylamino-ethyl)-4-(4-fluoro-3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-piperidin-1-yl}-5-vinyl-pyrimidin-4-ylamine	HCID 89442640	—

Reaction Steps

The title compound was prepared in an analogous manner as 6-{4-[1-(2-Dimethylamino-ethyl)-4-(4-fluoro-3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-piperidin-1-yl}-5-(4-fluoro-phenyl)-pyrimidin-4-ylamine using vinylboronic acid pinacol ester instead of 4-fluorophenylboronic acid. LC-MS: (M+1=504, obsd.=504).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09145392B2
Source dataset	uspto-grants-2015_09
ORD ID	ord-a59086c0da0542338b79399ab4d54f1a
Source note	uspto-grants-2015_09