6-(4-(1-(2-(Dimethylamino)ethyl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidin-1-yl)-5-ethylpyrimidin-4-amine → 5-(2-Cyclopropylethyl)-6-(4-(1-(2-(dimethylamino)ethyl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidin-1-yl)pyrimidin-4-amine

HRID 2284008Notes

Reaction equation

HRID 2284008 reaction equation
CN(C)CCN1C=C(C2C=CC(F)=C(C(F)(F)F)C=2)N=C1C1CCN(C2N=CN=C(N)C=2CC)CC1.[CH:37]1(/[CH:40]=[CH:41]/[C:42]2[C:43]([NH2:75])=[N:44][CH:45]=[N:46][C:47]=2[N:48]2[CH2:53][CH2:52][CH:51]([C:54]3[N:55]([CH2:70][CH2:71][N:72]([CH3:74])[CH3:73])[CH:56]=[C:57]([C:59]4[CH:64]=[CH:63][C:62]([F:65])=[C:61]([C:66]([F:69])([F:68])[F:67])[CH:60]=4)[N:58]=3)[CH2:50][CH2:49]2)[CH2:39][CH2:38]1>>[CH:37]1([CH2:40][CH2:41][C:42]2[C:43]([NH2:75])=[N:44][CH:45]=[N:46][C:47]=2[N:48]2[CH2:53][CH2:52][CH:51]([C:54]3[N:55]([CH2:70][CH2:71][N:72]([CH3:73])[CH3:74])[CH:56]=[C:57]([C:59]4[CH:64]=[CH:63][C:62]([F:65])=[C:61]([C:66]([F:69])([F:68])[F:67])[CH:60]=4)[N:58]=3)[CH2:50][CH2:49]2)[CH2:39][CH2:38]1

Participants

3

Reactant 2

HCID 894424656-(4-(1-(2-(Dimethylamino)ethyl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidin-1-yl)-5-ethylpyrimidin-4-amineHCID 89450671(E)-5-(2-cyclopropylvinyl)-6-(4-(1-(2-(dimethylamino)ethyl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidin-1-yl)pyrimidin-4-amine

Product 1

HCID 894506695-(2-Cyclopropylethyl)-6-(4-(1-(2-(dimethylamino)ethyl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidin-1-yl)pyrimidin-4-amine

Procedure

The title compound was prepared in an analogous manner as 6-(4-(1-(2-(dimethylamino)ethyl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidin-1-yl)-5-ethylpyrimidin-4-amine using (E)-5-(2-cyclopropylvinyl)-6-(4-(1-(2-(dimethylamino)ethyl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidin-1-yl)pyrimidin-4-amine. LC-MS: (M+1=546, obsd.=546).

Sources & evidence

ORD record
ord-57ff7636ac484261a4e1a5655ce13577
Source dataset
uspto-grants-2015_09
Patent number
US09145392B2

Reaction notes

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