6-(4-(1-(2-(Dimethylamino)ethyl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidin-1-yl)-5-ethylpyrimidin-4-amine → 6-(4-(1-(2-(Dimethylamino)ethyl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidin-1-yl)-5-(2-ethoxyethyl)pyrimidin-4-amine

HRID 2284009Notes

Reaction equation

HRID 2284009 reaction equation
CN(C)CCN1C=C(C2C=CC(F)=C(C(F)(F)F)C=2)N=C1C1CCN(C2N=CN=C(N)C=2CC)CC1.[CH3:37][N:38]([CH3:75])[CH2:39][CH2:40][N:41]1[CH:45]=[C:44]([C:46]2[CH:51]=[CH:50][C:49]([F:52])=[C:48]([C:53]([F:56])([F:55])[F:54])[CH:47]=2)[N:43]=[C:42]1[CH:57]1[CH2:62][CH2:61][N:60]([C:63]2[N:68]=[CH:67][N:66]=[C:65]([NH2:69])[C:64]=2/[CH:70]=[CH:71]/[O:72][CH2:73][CH3:74])[CH2:59][CH2:58]1>>[CH3:75][N:38]([CH3:37])[CH2:39][CH2:40][N:41]1[CH:45]=[C:44]([C:46]2[CH:51]=[CH:50][C:49]([F:52])=[C:48]([C:53]([F:55])([F:56])[F:54])[CH:47]=2)[N:43]=[C:42]1[CH:57]1[CH2:58][CH2:59][N:60]([C:63]2[N:68]=[CH:67][N:66]=[C:65]([NH2:69])[C:64]=2[CH2:70][CH2:71][O:72][CH2:73][CH3:74])[CH2:61][CH2:62]1

Participants

3

Reactant 2

HCID 894424656-(4-(1-(2-(Dimethylamino)ethyl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidin-1-yl)-5-ethylpyrimidin-4-amineHCID 89450670(E)-6-(4-(1-(2-(dimethylamino)ethyl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidin-1-yl)-5-(2-ethoxyvinyl)pyrimidin-4-amine

Product 1

HCID 894425486-(4-(1-(2-(Dimethylamino)ethyl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidin-1-yl)-5-(2-ethoxyethyl)pyrimidin-4-amine

Procedure

The title compound was prepared in an analogous manner as 6-(4-(1-(2-(dimethylamino)ethyl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidin-1-yl)-5-ethylpyrimidin-4-amine using (E)-6-(4-(1-(2-(dimethylamino)ethyl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidin-1-yl)-5-(2-ethoxyvinyl)pyrimidin-4-amine. LC-MS: (M+1=550, obsd.=550).

Sources & evidence

ORD record
ord-db8e935f67fe457093f1d14251c35a5f
Source dataset
uspto-grants-2015_09
Patent number
US09145392B2

Reaction notes

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