HRID2284015

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CC(F)C2)CC1

HCID89442593

未命名化合物

结构：CC1CN(CCn2cc(-c3ccc(F)c(C(F)(F)F)c3)nc2C2CCNCC2)C1

HCID89442642

未命名化合物

PRODUCTS

生成物

结构：CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CC(C)C2)CC1

HCID89450701

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in an analogous manner as 5-ethyl-6-(4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1-(2-(3-fluoroazetidin-1-yl)ethyl)-1H-imidazol-2-yl)piperidin-1-yl)pyrimidin-4-amine using 4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1-(2-(3-methylazetidin-1-yl)ethyl)-1H-imidazol-2-yl)piperidine instead of 4-[1-[2-(3-Fluoro-azetidin-1-yl)-ethyl]-4-(4-fluoro-3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-piperidine. LC-MS: (M+1=532, obsd.=532).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d46ef3d2127849499133e7c5c848c251
来源数据集: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09145392B2
来源说明: uspto-grants-2015_09

反应 SMILES

[CH2:1]([C:3]1[C:4]([NH2:38])=[N:5][CH:6]=[N:7][C:8]=1[N:9]1[CH2:14][CH2:13][CH:12]([C:15]2[N:16]([CH2:31][CH2:32][N:33]3[CH2:36][CH:35](F)[CH2:34]3)[CH:17]=[C:18]([C:20]3[CH:25]=[CH:24][C:23]([F:26])=[C:22]([C:27]([F:30])([F:29])[F:28])[CH:21]=3)[N:19]=2)[CH2:11][CH2:10]1)[CH3:2].F[C:40]1C=CC(C2N=C(C3CCNCC3)N(CCN3CC(C)C3)C=2)=CC=1C(F)(F)F>>[CH2:1]([C:3]1[C:4]([NH2:38])=[N:5][CH:6]=[N:7][C:8]=1[N:9]1[CH2:10][CH2:11][CH:12]([C:15]2[N:16]([CH2:31][CH2:32][N:33]3[CH2:34][CH:35]([CH3:40])[CH2:36]3)[CH:17]=[C:18]([C:20]3[CH:25]=[CH:24][C:23]([F:26])=[C:22]([C:27]([F:28])([F:29])[F:30])[CH:21]=3)[N:19]=2)[CH2:13][CH2:14]1)[CH3:2]