HCID 89442593, compound → 6-(4-(1-(2-(3,3-difluoroazetidin-1-yl)ethyl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidin-1-yl)-5-ethylpyrimidin-4-amine

HRID 2284016Notes

Reaction equation

HRID 2284016 reaction equation
[CH2:1]([C:3]1[C:4]([NH2:38])=[N:5][CH:6]=[N:7][C:8]=1[N:9]1[CH2:14][CH2:13][CH:12]([C:15]2[N:16]([CH2:31][CH2:32][N:33]3[CH2:36][CH:35]([F:37])[CH2:34]3)[CH:17]=[C:18]([C:20]3[CH:25]=[CH:24][C:23]([F:26])=[C:22]([C:27]([F:30])([F:29])[F:28])[CH:21]=3)[N:19]=2)[CH2:11][CH2:10]1)[CH3:2].[F:39]C1(F)CN(CCN2C=C(C3C=CC(F)=C(C(F)(F)F)C=3)N=C2C2CCNCC2)C1>>[F:37][C:35]1([F:39])[CH2:34][N:33]([CH2:32][CH2:31][N:16]2[CH:17]=[C:18]([C:20]3[CH:25]=[CH:24][C:23]([F:26])=[C:22]([C:27]([F:28])([F:30])[F:29])[CH:21]=3)[N:19]=[C:15]2[CH:12]2[CH2:11][CH2:10][N:9]([C:8]3[N:7]=[CH:6][N:5]=[C:4]([NH2:38])[C:3]=3[CH2:1][CH3:2])[CH2:14][CH2:13]2)[CH2:36]1

Participants

3

Reactant 2

HCID 89442593HCID 89442593, compoundHCID 1177008694-(1-(2-(3,3-difluoroazetidin-1-yl)ethyl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidine

Product 1

HCID 894455536-(4-(1-(2-(3,3-difluoroazetidin-1-yl)ethyl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidin-1-yl)-5-ethylpyrimidin-4-amine

Procedure

The title compound was prepared in an analogous manner as 5-ethyl-6-(4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1-(2-(3-fluoroazetidin-1-yl)ethyl)-1H-imidazol-2-yl)piperidin-1-yl)pyrimidin-4-amine using 4-(1-(2-(3,3-difluoroazetidin-1-yl)ethyl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidine instead of 4-[1-[2-(3-Fluoro-azetidin-1-yl)-ethyl]-4-(4-fluoro-3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-piperidine.

Sources & evidence

ORD record
ord-83cbed13e8b84e5d811ba43d8e0a6036
Source dataset
uspto-grants-2015_09
Patent number
US09145392B2

Reaction notes

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