HRID2284023
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 120 °C
PROCEDURE
实验过程
A reaction mixture of 6-Chloro-5-ethyl-pyrimidin-4-ylamine (50.00 mg; 0.32 mmol; 1.00 eq.), 3-[1-(2-Azetidin-1-yl-ethyl)-2-piperidin-4-yl-1H-imidazol-4-yl]-5-trifluoromethyl-pyridine hydrochloride (3) (155.08 mg; 0.32 mmol; 1.00 eq.), and Cs2CO3 (206.74 mg; 0.63 mmol; 4.00 eq.) in DMSO 1.0 ml was stirred at 120° C. for 2 days, purified by HPLC, title compound 81 mg, 41.5%. LC-MS: (M+1=501, obsd.=501).
WORKUP
后处理
- custompurified by HPLC, title compound 81 mg, 41.5%