HCID 89442703, compound → 6-(4-(1-(2-(azetidin-1-yl)ethyl)-4-(3-(trifluoromethoxy)phenyl)-1H-imidazol-2-yl)piperidin-1-yl)-5-ethylpyrimidin-4-amine

HRID 2284024Notes

Reaction equation

HRID 2284024 reaction equation
N1(CCN2C=C(C3C=NC=C(C(F)(F)F)C=3)N=C2C2CCN([C:28]3[N:33]=[CH:32][N:31]=[C:30]([NH2:34])[C:29]=3[CH2:35][CH3:36])CC2)CCC1.[N:37]1([CH2:41][CH2:42][N:43]2[CH:47]=[C:46]([C:48]3[CH:53]=[CH:52][CH:51]=[C:50]([O:54][C:55]([F:58])([F:57])[F:56])[CH:49]=3)[N:45]=[C:44]2[CH:59]2[CH2:64][CH2:63][NH:62][CH2:61][CH2:60]2)[CH2:40][CH2:39][CH2:38]1>>[N:37]1([CH2:41][CH2:42][N:43]2[CH:47]=[C:46]([C:48]3[CH:53]=[CH:52][CH:51]=[C:50]([O:54][C:55]([F:58])([F:56])[F:57])[CH:49]=3)[N:45]=[C:44]2[CH:59]2[CH2:60][CH2:61][N:62]([C:28]3[N:33]=[CH:32][N:31]=[C:30]([NH2:34])[C:29]=3[CH2:35][CH3:36])[CH2:63][CH2:64]2)[CH2:40][CH2:39][CH2:38]1

Participants

3

Reactant 2

HCID 89442703HCID 89442703, compoundHCID 894428754-(1-(2-(azetidin-1-yl)ethyl)-4-(3-(trifluoromethoxy)phenyl)-1H-imidazol-2-yl)piperidine

Product 1

HCID 894503106-(4-(1-(2-(azetidin-1-yl)ethyl)-4-(3-(trifluoromethoxy)phenyl)-1H-imidazol-2-yl)piperidin-1-yl)-5-ethylpyrimidin-4-amine

Procedure

The title compound was prepared in an analogous manner as 6-(4-(1-(2-(azetidin-1-yl)ethyl)-4-(5-(trifluoromethyl)pyridin-3-yl)-1H-imidazol-2-yl)piperidin-1-yl)-5-ethylpyrimidin-4-amine of using 4-(1-(2-(azetidin-1-yl)ethyl)-4-(3-(trifluoromethoxy)phenyl)-1H-imidazol-2-yl)piperidine instead of 3-(1-(2-(azetidin-1-yl)ethyl)-2-(piperidin-4-yl)-1H-imidazol-4-yl)-5-(trifluoromethyl)pyridine hydrochloride salt. LC-MS: (M+1=516, obsd.=516).

Sources & evidence

ORD record
ord-92eae532ede9447c9ee141a991aba155
Source dataset
uspto-grants-2015_09
Patent number
US09145392B2

Reaction notes

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