Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | HCID 89442612 | HCID 89442612 | — |
| Reactant | 4-[1-(2-azetidin-1-yl-ethyl)-4-(4-fluoro-3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-piperidine trifluoroacetate | HCID 89442764 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 89450266 | HCID 89450266 | 46% |
Reaction Steps
A reaction mixture of 6-Chloro-5-(2,2,2-trifluoro-ethoxy)-pyrimidin-4-ylamine (45.00 mg; 0.20 mmol; 1.00 eq.), 4-[1-(2-Azetidin-1-yl-ethyl)-4-(4-fluoro-3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-piperidine trifluoroacetate (2) (123.48 mg; 0.20 mmol; 1.00 eq.), and Cs2CO3 (257.71 mg; 0.79 mmol; 4.00 eq.) in DMSO 1.0 ml was stirred at 120° C. for 5 days. Purified by HPLC, collected title product 54 mg, yield 39.8%. LC-MS: (M+1=588, obsd.=588).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09145392B2 |
|---|
| Source dataset | uspto-grants-2015_09 |
|---|
| ORD ID | ord-be3e376fd47a495ba92b029b8f604d0b |
|---|
| Source note | uspto-grants-2015_09 |
|---|
