HCID 89442703, compound → 5-(2-(1-(6-amino-5-ethylpyrimidin-4-yl)piperidin-4-yl)-1-(2-(azetidin-1-yl)ethyl)-1H-imidazol-4-yl)-2-fluorobenzamide
Reaction equation
N1(CCN2C=C(C3C=NC=C(C(F)(F)F)C=3)N=C2C2CCN([C:28]3[N:33]=[CH:32][N:31]=[C:30]([NH2:34])[C:29]=3[CH2:35][CH3:36])CC2)CCC1.[N:37]1([CH2:41][CH2:42][N:43]2[CH:47]=[C:46]([C:48]3[CH:49]=[CH:50][C:51]([F:57])=[C:52]([CH:56]=3)[C:53]([NH2:55])=[O:54])[N:45]=[C:44]2[CH:58]2[CH2:63][CH2:62][NH:61][CH2:60][CH2:59]2)[CH2:40][CH2:39][CH2:38]1>>[NH2:34][C:30]1[N:31]=[CH:32][N:33]=[C:28]([N:61]2[CH2:60][CH2:59][CH:58]([C:44]3[N:43]([CH2:42][CH2:41][N:37]4[CH2:38][CH2:39][CH2:40]4)[CH:47]=[C:46]([C:48]4[CH:49]=[CH:50][C:51]([F:57])=[C:52]([CH:56]=4)[C:53]([NH2:55])=[O:54])[N:45]=3)[CH2:63][CH2:62]2)[C:29]=1[CH2:35][CH3:36]Participants
3
Procedure
The title compound was prepared in an analogous manner as 6-(4-(1-(2-(azetidin-1-yl)ethyl)-4-(5-(trifluoromethyl)pyridin-3-yl)-1H-imidazol-2-yl)piperidin-1-yl)-5-ethylpyrimidin-4-amine of using 5-(1-(2-(azetidin-1-yl)ethyl)-2-(piperidin-4-yl)-1H-imidazol-4-yl)-2-fluorobenzamide instead of 3-(1-(2-(azetidin-1-yl)ethyl)-2-(piperidin-4-yl)-1H-imidazol-4-yl)-5-(trifluoromethyl)pyridine hydrochloride salt. LC-MS: (M+1=493, obsd.=493).
Sources & evidence
- ORD record
- ord-748a349a4583422499c48663952e5f38
- Source dataset
- uspto-grants-2015_09
- Patent number
- US09145392B2
Reaction notes
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