Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 6-Chloro-5-methoxypyrimidin-4-amine | HCID 78721 | — |
| Reactant | HCID 89442760 | HCID 89442760 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 89442959 | HCID 89442959 | — |
Reaction Steps
A reaction mixture of 6-Chloro-5-methoxy-pyrimidin-4-ylamine (45.00 mg; 0.28 mmol; 1.00 eq.), 4-[1-(2-Azetidin-1-yl-ethyl)-2-piperidin-4-yl-1H-imidazol-4-yl]-2-trifluoromethyl-pyridine hydrochloride (4) (148.13 mg; 0.28 mmol; 1.00 eq.), and Cs2CO3 (367.53 mg; 1.13 mmol; 4.00 eq.) in DMSO 1.0 ml was stirred at 120° C. for 2 days, purified by HPLC collected title compound 17 mg. LC-MS: (M+1=503, obsd.=503).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09145392B2 |
|---|
| Source dataset | uspto-grants-2015_09 |
|---|
| ORD ID | ord-5a78a27ea432460c813c7fe02d6d6912 |
|---|
| Source note | uspto-grants-2015_09 |
|---|
