6-Chloro-5-ethoxypyrimidin-4-amine → HCID 89442638, compound

HRID 2284040Notes

Reaction equation

HRID 2284040 reaction equation
[N:1]1([CH2:5][CH2:6][N:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][N:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=3)[N:9]=[C:8]2[CH:22]2[CH2:27][CH2:26][N:25]([C:28]3[N:33]=[CH:32][N:31]=[C:30]([NH2:34])[C:29]=3[O:35][CH3:36])[CH2:24][CH2:23]2)[CH2:4][CH2:3][CH2:2]1.Cl[C:38]1N=CN=C(N)C=1OCC>>[N:1]1([CH2:5][CH2:6][N:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][N:15]=[C:14]([C:18]([F:19])([F:20])[F:21])[CH:13]=3)[N:9]=[C:8]2[CH:22]2[CH2:27][CH2:26][N:25]([C:28]3[N:33]=[CH:32][N:31]=[C:30]([NH2:34])[C:29]=3[O:35][CH2:36][CH3:38])[CH2:24][CH2:23]2)[CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 735550476-Chloro-5-ethoxypyrimidin-4-amineHCID 89442959HCID 89442959, compound

Product 1

HCID 89442638HCID 89442638, compound

Procedure

The title compound was prepared in an analogous manner as 6-(4-(1-(2-(azetidin-1-yl)ethyl)-4-(2-(trifluoromethyl)pyridin-4-yl)-1H-imidazol-2-yl)piperidin-1-yl)-5-methoxypyrimidin-4-amine using 6-Chloro-5-ethoxy-pyrimidin-4-ylamine instead of 6-Chloro-5-methoxy-pyrimidin-4-ylamine. LC-MS: (M+1=517, obsd.=517).

Sources & evidence

ORD record
ord-cc13cdc40a5444aa882e255202784dd1
Source dataset
uspto-grants-2015_09
Patent number
US09145392B2

Reaction notes

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