HCID 89442470, compound → 6-(4-(1-(2-(azetidin-1-yl)ethyl)-4-(2-(trifluoromethyl)pyridin-4-yl)-1H-imidazol-2-yl)piperidin-1-yl)-5-isopropoxypyrimidin-4-amine

HRID 2284041Notes

Reaction equation

HRID 2284041 reaction equation
[N:1]1([CH2:5][CH2:6][N:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][N:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=3)[N:9]=[C:8]2[CH:22]2[CH2:27][CH2:26][N:25](C3N=CN=C(N)C=3OC)[CH2:24][CH2:23]2)[CH2:4][CH2:3][CH2:2]1.Cl[C:38]1[N:43]=[CH:42][N:41]=[C:40]([NH2:44])[C:39]=1[O:45][CH:46]([CH3:48])[CH3:47]>>[N:1]1([CH2:5][CH2:6][N:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][N:15]=[C:14]([C:18]([F:21])([F:19])[F:20])[CH:13]=3)[N:9]=[C:8]2[CH:22]2[CH2:23][CH2:24][N:25]([C:38]3[N:43]=[CH:42][N:41]=[C:40]([NH2:44])[C:39]=3[O:45][CH:46]([CH3:48])[CH3:47])[CH2:26][CH2:27]2)[CH2:2][CH2:3][CH2:4]1

Participants

3

Reactant 2

HCID 89442470HCID 89442470, compoundHCID 89442959HCID 89442959, compound

Product 1

HCID 1177004166-(4-(1-(2-(azetidin-1-yl)ethyl)-4-(2-(trifluoromethyl)pyridin-4-yl)-1H-imidazol-2-yl)piperidin-1-yl)-5-isopropoxypyrimidin-4-amine

Procedure

The title compound was prepared in an analogous manner as 6-(4-(1-(2-(azetidin-1-yl)ethyl)-4-(2-(trifluoromethyl)pyridin-4-yl)-1H-imidazol-2-yl)piperidin-1-yl)-5-methoxypyrimidin-4-amine using 6-chloro-5-isopropoxypyrimidin-4-amine instead of 6-Chloro-5-methoxy-pyrimidin-4-ylamine. LC-MS: (M+1=531, obsd.=531).

Sources & evidence

ORD record
ord-61ca3f42870243b9b7df07c07992f5ad
Source dataset
uspto-grants-2015_09
Patent number
US09145392B2

Reaction notes

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