HCID 89442612, compound → HCID 117700328, compound

HRID 2284042Notes

Reaction equation

HRID 2284042 reaction equation
[N:1]1([CH2:5][CH2:6][N:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][N:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=3)[N:9]=[C:8]2[CH:22]2[CH2:27][CH2:26][N:25]([C:28]3[N:33]=[CH:32][N:31]=[C:30]([NH2:34])[C:29]=3[O:35][CH3:36])[CH2:24][CH2:23]2)[CH2:4][CH2:3][CH2:2]1.ClC1N=CN=C(N)C=1OC[C:47]([F:50])([F:49])[F:48]>>[N:1]1([CH2:5][CH2:6][N:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][N:15]=[C:14]([C:18]([F:19])([F:20])[F:21])[CH:13]=3)[N:9]=[C:8]2[CH:22]2[CH2:27][CH2:26][N:25]([C:28]3[N:33]=[CH:32][N:31]=[C:30]([NH2:34])[C:29]=3[O:35][CH2:36][C:47]([F:50])([F:49])[F:48])[CH2:24][CH2:23]2)[CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 89442612HCID 89442612, compoundHCID 89442959HCID 89442959, compound

Product 1

HCID 117700328HCID 117700328, compound

Procedure

The title compound was prepared in an analogous manner as 6-(4-(1-(2-(azetidin-1-yl)ethyl)-4-(2-(trifluoromethyl)pyridin-4-yl)-1H-imidazol-2-yl)piperidin-1-yl)-5-methoxypyrimidin-4-amine using 6-chloro-5-(2,2,2-trifluoroethoxy)pyrimidin-4-amine instead of 6-Chloro-5-methoxy-pyrimidin-4-ylamine. LC-MS: (M+1=571, obsd.=571).

Sources & evidence

ORD record
ord-503ba086b7904c66bfd7191910b7a230
Source dataset
uspto-grants-2015_09
Patent number
US09145392B2

Reaction notes

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