Cesium carbonate → HCID 89450673, compound

Participants

Reaction Conditions

Reaction Steps

A reaction mixture of 6-Chloro-5-ethyl-pyrimidin-4-ylamine (45.00 mg; 0.29 mmol; 1.00 eq.), 2-[1-(2-Azetidin-1-yl-ethyl)-2-piperidin-4-yl-1H-imidazol-4-yl]-6-chloropyridine hydrochloride (4) (140.40 mg; 0.29 mmol; 1.00 eq.), and Cs2CO3 (372.13 mg; 1.14 mmol; 4.00 eq.) in DMSO 1.0 ml was stirred at 120° C. for 2 days, purified by HPLC, collected title compound 36 mg. LC-MS (M+1=467, obsd.=467).

Provenance & Evidence