反应详情

温度

100 °C

A reaction mixture of 5-bromo-6-chloro-pyrimidin-4-ylamine (370.00 mg; 1.78 mmol; 1.00 eq.), 2-[4-(4-fluoro-3-methyl-phenyl)-2-piperidin-4-yl-imidazol-1-yl]-ethanol hydrochloride (3) (732.67 mg; 1.78 mmol; 1.00 eq.), and Cs2CO3 (2313.40 mg; 7.10 mmol; 4.00 eq.) in DMSO 10 ml, stirred at 100° C. for overnight, cooled, poured into water 60 ml, stirred for 15 mins, filtered, collected light yellow solid, which was washed with water, dried, got title compound, 750 mg, 88.9%.

1. temperaturecooled
2. stirringstirred for 15 mins
3. filtrationfiltered
4. customcollected light yellow solid, which
5. washwas washed with water
6. customdried