HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2284059Generated: October 31, 2026
Cyclopropylamine → 6-(4-(1-(2-(cyclopropylamino)ethyl)-4-(4-fluoro-3-methylphenyl)-1H-imidazol-2-yl)piperidin-1-yl)-5-(1H-pyrazol-4-yl)pyrimidin-4-amine
https://huagongshe.com/reaction/2284059
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | 4-(4-Amino-6-{4-[4-(4-fluoro-3-methyl-phenyl)-1-(2-methanesulfonyloxy-ethyl)-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-5-yl)-pyrazole-1-carboxylic acid tert-butyl ester | HCID 89442662 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-(4-(1-(2-(cyclopropylamino)ethyl)-4-(4-fluoro-3-methylphenyl)-1H-imidazol-2-yl)piperidin-1-yl)-5-(1H-pyrazol-4-yl)pyrimidin-4-amine | HCID 89442545 | — |
Reaction Steps
4-(4-Amino-6-{4-[4-(4-fluoro-3-methyl-phenyl)-1-(2-methanesulfonyloxy-ethyl)-1H-imidazol-2-yl]-piperidin-1-yl}-pyrimidin-5-yl)-pyrazole-1-carboxylic acid tert-butyl ester (100.00 mg; 0.16 mmol; 1.00 eq.) in seal tube was added THF 2 ml and cyclopropylamine (0.70 ml; 9.81 mmol; 62.84 eq.), stirred at 50° C. for overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09145392B2 |
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| Source dataset | uspto-grants-2015_09 |
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| ORD ID | ord-87389f28cab045adaf4d079231f12b2a |
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| Source note | uspto-grants-2015_09 |
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