2-Ethenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane → HCID 71504255, compound

HRID 2284060Notes

Reaction equation

HRID 2284060 reaction equation
[N:1]1([CH2:5][CH2:6][N:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][N:15]=[C:14]([CH:18]([CH3:20])[CH3:19])[CH:13]=3)[N:9]=[C:8]2[CH:21]2[CH2:26][CH2:25][N:24]([C:27]3[N:32]=[CH:31][N:30]=[C:29]([NH2:33])[C:28]=3Br)[CH2:23][CH2:22]2)[CH2:4][CH2:3][CH2:2]1.[CH3:35][C:36]1(C)C(C)(C)OB(C=C)O1>O>[N:1]1([CH2:5][CH2:6][N:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][N:15]=[C:14]([CH:18]([CH3:20])[CH3:19])[CH:13]=3)[N:9]=[C:8]2[CH:21]2[CH2:26][CH2:25][N:24]([C:27]3[N:32]=[CH:31][N:30]=[C:29]([NH2:33])[C:28]=3[CH:35]=[CH2:36])[CH2:23][CH2:22]2)[CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 52330122-Ethenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneHCID 894427436-{4-[1-(2-Azetidin-1-yl-ethyl)-4-(2-isopropyl-pyridin-4-yl)-1H-imidazol-2-yl]-piperidin-1-yl}-5-bromo-pyrimidin-4-ylamine

Product 1

HCID 71504255HCID 71504255, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

a mixture of 6-{4-[1-(2-Azetidin-1-yl-ethyl)-4-(2-isopropyl-pyridin-4-yl)-1H-imidazol-2-yl]-piperidin-1-yl}-5-bromo-pyrimidin-4-ylamine (70.00 mg; 0.13 mmol; 1.00 eq.), 4,4,5,5-Tetramethyl-2-vinyl-[1,3,2]dioxaborolane (0.03 ml; 0.16 mmol; 1.20 eq.), (4.77 mg; 0.01 mmol; 0.07 eq.) and in doxane 15 ml and water 1.5 ml, stirred at 50 C for overnight.

Sources & evidence

ORD record
ord-60d82f6dc44b442a99f1855161fe6b41
Source dataset
uspto-grants-2015_09
Patent number
US09145392B2

Reaction notes

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