4-(Morpholin-4-yl)benzoic acid → HCID 178481116, compound

HRID 2284104Notes

Reaction equation

HRID 2284104 reaction equation
[NH2:1][C:2]1[CH:21]=[CH:20][C:5]2[N:6]=[C:7]([C:9]3[CH:19]=[CH:18][C:12]4C(C)CN[O:16][C:11]=4[CH:10]=3)[NH:8][C:4]=2[CH:3]=1.[O:22]1[CH2:27][CH2:26][N:25]([C:28]2[CH:36]=[CH:35][C:31]([C:32]([OH:34])=O)=[CH:30][CH:29]=2)[CH2:24][CH2:23]1>>[CH3:7][N:6]1[CH2:5][CH2:4][O:16][C:11]2[CH:10]=[C:9]([C:7]3[NH:6][C:5]4[CH:20]=[CH:21][C:2]([NH:1][C:32](=[O:34])[C:31]5[CH:30]=[CH:29][C:28]([N:25]6[CH2:24][CH2:23][O:22][CH2:27][CH2:26]6)=[CH:36][CH:35]=5)=[CH:3][C:4]=4[N:8]=3)[CH:19]=[CH:18][C:12]1=2

Participants

3

Reactant 2

HCID 3452784-(Morpholin-4-yl)benzoic acidHCID 67112557HCID 67112557, compound

Product 1

HCID 178481116HCID 178481116, compound

Procedure

Compound 169 was prepared according to the procedure similar to that described in Scheme III from 5-amino-2-(4-methyl-3,4-dihydrobenzoxazin-7-yl)benzimidazole and 4-morpholinobenzoic acid. [M+H]+ calcd for C27H27N5O3: 470.21; found: 496.96.

Sources & evidence

ORD record
ord-12bcf84d87bd4d28adf6ee2c9090effa
Source dataset
uspto-grants-2015_09
Patent number
US09144557B2

Reaction notes

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