N-cyclopropyl-4-formylbenzamide → N-cyclopropyl-4-(5-(4-fluorobenzamido)-1H-benzo[d]imidazol-2-yl)benzamide

HRID 2284145Notes

Reaction equation

HRID 2284145 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([NH:13][C:14](=[O:22])[C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[CH:7]=[CH:8][C:9]=1[N+:10]([O-])=O)([O-])=O.[CH:23]1([NH:26][C:27]([C:29]2[CH:36]=[CH:35][C:32]([CH:33]=O)=[CH:31][CH:30]=2)=[O:28])[CH2:25][CH2:24]1>>[CH:23]1([NH:26][C:27](=[O:28])[C:29]2[CH:36]=[CH:35][C:32]([C:33]3[NH:10][C:9]4[CH:8]=[CH:7][C:6]([NH:13][C:14](=[O:22])[C:15]5[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=5)=[CH:5][C:4]=4[N:1]=3)=[CH:31][CH:30]=2)[CH2:24][CH2:25]1

Participants

3

Reactant 2

HCID 28818865N-cyclopropyl-4-formylbenzamideHCID 86673972N-(3,4-dinitrophenyl)-4-fluorobenzamide

Product 1

HCID 178521799N-cyclopropyl-4-(5-(4-fluorobenzamido)-1H-benzo[d]imidazol-2-yl)benzamide

Procedure

Compound 234 was prepared according to the procedure similar to that described in Scheme III from N-(3,4-dinitrophenyl)-4-fluorobenzamide and 4-cyclopropylaminocarbonylbenzaldehyde. [M+H]+ calcd for C24H19FN4O2: 415.16; found: 415.53.

Sources & evidence

ORD record
ord-0d865e2995124243ae7f5bb24d25ec42
Source dataset
uspto-grants-2015_09
Patent number
US09144557B2

Reaction notes

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