4-Dimethylaminobenzoate → N-(1-(4-Benzamidophenyl)-1H-indazol-5-yl)-4-dimethylaminobenzamide

HRID 2284197Notes

Reaction equation

[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:11]1[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=1)[N:6]=[CH:5]2.[CH3:18][N:19]([CH3:29])[C:20]1[CH:28]=[CH:27][C:23]([C:24]([O-:26])=O)=[CH:22][CH:21]=1>>[C:24]([NH:17][C:14]1[CH:15]=[CH:16][C:11]([N:7]2[C:8]3[C:4](=[CH:3][C:2]([NH:1][C:24](=[O:26])[C:23]4[CH:22]=[CH:21][C:20]([N:19]([CH3:18])[CH3:29])=[CH:28][CH:27]=4)=[CH:10][CH:9]=3)[CH:5]=[N:6]2)=[CH:12][CH:13]=1)(=[O:26])[C:23]1[CH:27]=[CH:28][CH:20]=[CH:21][CH:22]=1

Participants

Reactant 2

HCID 69502454-Dimethylaminobenzoate

HCID 834142075-Amino-1-(4-aminophenyl)indazole

Product 1

HCID 67113098N-(1-(4-Benzamidophenyl)-1H-indazol-5-yl)-4-dimethylaminobenzamide

Procedure

Compound 375 was prepared according to the procedure described in Scheme IV from 5-amino-1-(4-aminophenyl)indazole and 4-dimethylaminobenzoate. 1H NMR (500 MHz, DMSO-d6) δ 10.45 (s, 1H), 10.01 (s, 1H), 8.37 (d, J=1.5 Hz, 1H), 8.33 (d, J=1 Hz, 1H), 8.01-7.78 (m, 11H), 7.55 (t, J=8 Hz, 2H), 6.77 (d, J=9 Hz, 2H), 3.00 (s, 6H).

Sources & evidence

ORD record: ord-5f2701266f804f01b04cf18a6cae0679
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09144557B2

Reaction notes

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