4-Dimethylaminobenzoate → N-(1-(4-Amino-2-fluorophenyl)-1H-indazol-5-yl)-4-dimethylaminobenzamide

HRID 2284201Notes

Reaction equation

[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:11]1[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][C:12]=1[F:18])[N:6]=[CH:5]2.[CH3:19][N:20]([CH3:30])[C:21]1[CH:29]=[CH:28][C:24]([C:25]([O-])=[O:26])=[CH:23][CH:22]=1>>[NH2:17][C:14]1[CH:15]=[CH:16][C:11]([N:7]2[C:8]3[C:4](=[CH:3][C:2]([NH:1][C:25](=[O:26])[C:24]4[CH:23]=[CH:22][C:21]([N:20]([CH3:19])[CH3:30])=[CH:29][CH:28]=4)=[CH:10][CH:9]=3)[CH:5]=[N:6]2)=[C:12]([F:18])[CH:13]=1

Participants

Reactant 2

HCID 69502454-Dimethylaminobenzoate

HCID 866739875-Amino-1-(4-amino-2-fluorophenyl)indazole

Product 1

HCID 67113126N-(1-(4-Amino-2-fluorophenyl)-1H-indazol-5-yl)-4-dimethylaminobenzamide

Procedure

Compound 388 was prepared according to the procedure described in Scheme IV from 5-amino-1-(4-amino-2-fluorophenyl)indazole and 4-dimethylaminobenzoate. [M+H]+ calcd for C22H20FN5O: 390.17; found: 389.96.

Sources & evidence

ORD record: ord-1bfd5cc32c3c4180b4e5d52984b08c51
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09144557B2

Reaction notes

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