4-(4-Hydroxypiperidino)benzoate → N-(1-(4-Cyanophenyl)-1H-indazol-5-yl)-4-(4-hydroxypiperidino)benzamide

HRID 2284204Notes

Reaction equation

HRID 2284204 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:11]1[CH:16]=[CH:15][C:14]([C:17]#[N:18])=[CH:13][CH:12]=1)[N:6]=[CH:5]2.[OH:19][CH:20]1[CH2:25][CH2:24][N:23]([C:26]2[CH:34]=[CH:33][C:29]([C:30]([O-])=[O:31])=[CH:28][CH:27]=2)[CH2:22][CH2:21]1>>[C:17]([C:14]1[CH:15]=[CH:16][C:11]([N:7]2[C:8]3[C:4](=[CH:3][C:2]([NH:1][C:30](=[O:31])[C:29]4[CH:28]=[CH:27][C:26]([N:23]5[CH2:24][CH2:25][CH:20]([OH:19])[CH2:21][CH2:22]5)=[CH:34][CH:33]=4)=[CH:10][CH:9]=3)[CH:5]=[N:6]2)=[CH:12][CH:13]=1)#[N:18]

Participants

3

Reactant 2

HCID 286044354-(4-Hydroxypiperidino)benzoateHCID 834142885-Amino-1-(4-cyanophenyl)indazole

Product 1

HCID 67112530N-(1-(4-Cyanophenyl)-1H-indazol-5-yl)-4-(4-hydroxypiperidino)benzamide

Procedure

Compound 404 was prepared according to the procedure described in Scheme IV from 5-amino-1-(4-cyanophenyl)indazole and 4-(4-hydroxypiperidino)benzoate. [M+H]+ calcd for C26H23N5O2: 438.19; found: 437.99.

Sources & evidence

ORD record
ord-18ad4c3421654c4eb02dd8cc70978ced
Source dataset
uspto-grants-2015_09
Patent number
US09144557B2

Reaction notes

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