4-(4-Hydroxypiperidino)benzoate → N-(1-(4-Aminophenyl)-1H-indazol-5-yl)-4-(4-hydroxypiperidin-1-yl)benzamide

HRID 2284252Notes

Reaction equation

HRID 2284252 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:11]1[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=1)[N:6]=[CH:5]2.[OH:18][CH:19]1[CH2:24][CH2:23][N:22]([C:25]2[CH:33]=[CH:32][C:28]([C:29]([O-])=[O:30])=[CH:27][CH:26]=2)[CH2:21][CH2:20]1>>[NH2:17][C:14]1[CH:15]=[CH:16][C:11]([N:7]2[C:8]3[C:4](=[CH:3][C:2]([NH:1][C:29](=[O:30])[C:28]4[CH:27]=[CH:26][C:25]([N:22]5[CH2:23][CH2:24][CH:19]([OH:18])[CH2:20][CH2:21]5)=[CH:33][CH:32]=4)=[CH:10][CH:9]=3)[CH:5]=[N:6]2)=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 286044354-(4-Hydroxypiperidino)benzoateHCID 834142075-Amino-1-(4-aminophenyl)indazole

Product 1

HCID 67112730N-(1-(4-Aminophenyl)-1H-indazol-5-yl)-4-(4-hydroxypiperidin-1-yl)benzamide

Procedure

Compound 515 was prepared according to the procedure described in Scheme IV from 5-amino-1-(4-aminophenyl)indazole and 4-(4-hydroxypiperidin-1-yl)benzoate. [M+H]+ calcd for C25H25N5O2: 428.20; found: 427.93.

Sources & evidence

ORD record
ord-cb96e3b8e5694178bfb5a5ab6a434774
Source dataset
uspto-grants-2015_09
Patent number
US09144557B2

Reaction notes

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