1H-indole-6-carboxylic acid → N-(4-(5-(1H-Indole-6-carboxamido)-1H-indazol-1-yl)phenyl)-1H-indole-6-carboxamide

HRID 2284253Notes

Reaction equation

HRID 2284253 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:11]1[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=1)[N:6]=[CH:5]2.[NH:18]1[C:26]2[C:21](=[CH:22][CH:23]=[C:24]([C:27]([OH:29])=O)[CH:25]=2)[CH:20]=[CH:19]1>>[NH:18]1[C:26]2[C:21](=[CH:22][CH:23]=[C:24]([C:27]([NH:1][C:2]3[CH:3]=[C:4]4[C:8](=[CH:9][CH:10]=3)[N:7]([C:11]3[CH:16]=[CH:15][C:14]([NH:17][C:27]([C:24]5[CH:25]=[C:26]6[C:21]([CH:20]=[CH:19][NH:18]6)=[CH:22][CH:23]=5)=[O:29])=[CH:13][CH:12]=3)[N:6]=[CH:5]4)=[O:29])[CH:25]=2)[CH:20]=[CH:19]1

Participants

3

Reactant 2

HCID 5952301H-indole-6-carboxylic acidHCID 834142075-Amino-1-(4-aminophenyl)indazole

Product 1

HCID 67113581N-(4-(5-(1H-Indole-6-carboxamido)-1H-indazol-1-yl)phenyl)-1H-indole-6-carboxamide

Procedure

Compound 523 was prepared according to the procedure described in Scheme IV from 5-amino-1-(4-aminophenyl)indazole and 1H-indole-6-carboxylic acid. [M+H]+ calcd for C31H22N6O2: 511.18; found: 511.02.

Sources & evidence

ORD record
ord-1c19e343e4854084b18f4a1eb0c9ce82
Source dataset
uspto-grants-2015_09
Patent number
US09144557B2

Reaction notes

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