4-(4-Morpholinophenyl)aminocarbonylbenzaldehyde → 4-(6-(2-Methylthiazol-4-ylmethoxy)-1H-benzo[d]imidazol-2-yl)-N-(4-morpholinophenyl)benzamide

HRID 2284263Notes

Reaction equation

HRID 2284263 reaction equation
[CH3:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[C:11]([N+:18]([O-])=O)[CH:10]=2)[N:6]=1.[O:21]1[CH2:26][CH2:25][N:24]([C:27]2[CH:32]=[CH:31][C:30]([NH:33][C:34]([C:36]3[CH:43]=[CH:42][C:39]([CH:40]=O)=[CH:38][CH:37]=3)=[O:35])=[CH:29][CH:28]=2)[CH2:23][CH2:22]1>>[CH3:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]3[N:15]=[C:40]([C:39]4[CH:38]=[CH:37][C:36]([C:34]([NH:33][C:30]5[CH:29]=[CH:28][C:27]([N:24]6[CH2:23][CH2:22][O:21][CH2:26][CH2:25]6)=[CH:32][CH:31]=5)=[O:35])=[CH:43][CH:42]=4)[NH:18][C:11]=3[CH:10]=2)[N:6]=1

Participants

3

Reactant 2

HCID 866739754-(4-Morpholinophenyl)aminocarbonylbenzaldehydeHCID 866740041-(2-Methylthiazol-4-yl)methoxy-3,4-dinitrobenzene

Product 1

HCID 676867784-(6-(2-Methylthiazol-4-ylmethoxy)-1H-benzo[d]imidazol-2-yl)-N-(4-morpholinophenyl)benzamide

Procedure

Compound 622 was prepared according to the procedure similar to that described in Scheme III from 1-(2-methylthiazol-4-yl)methoxy-3,4-dinitrobenzene and 4-(4-(4-morpholinophenyl)aminocarbonylbenzaldehyde. [M+H]+ calcd for C29H27N5O3S: 526.18; found: 526.06.

Sources & evidence

ORD record
ord-c7c9dc737cdc4eb48b1613dc6e70e968
Source dataset
uspto-grants-2015_09
Patent number
US09144557B2

Reaction notes

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