4-(4-Morpholinophenyl)aminocarbonylbenzaldehyde → 4-(6-(2-Methoxyethyloxy)-1H-benzo[d]imidazol-2-yl)-N-(4-morpholinophenyl)benzamide

HRID 2284273Notes

Reaction equation

HRID 2284273 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[C:8]([N+:15]([O-])=O)[CH:7]=1.[O:18]1[CH2:23][CH2:22][N:21]([C:24]2[CH:29]=[CH:28][C:27]([NH:30][C:31]([C:33]3[CH:40]=[CH:39][C:36]([CH:37]=O)=[CH:35][CH:34]=3)=[O:32])=[CH:26][CH:25]=2)[CH2:20][CH2:19]1>>[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]2[N:12]=[C:37]([C:36]3[CH:35]=[CH:34][C:33]([C:31]([NH:30][C:27]4[CH:26]=[CH:25][C:24]([N:21]5[CH2:20][CH2:19][O:18][CH2:23][CH2:22]5)=[CH:29][CH:28]=4)=[O:32])=[CH:40][CH:39]=3)[NH:15][C:8]=2[CH:7]=1

Participants

3

Reactant 2

HCID 866739754-(4-Morpholinophenyl)aminocarbonylbenzaldehydeHCID 866740102-Methoxyethoxy-3,4-dinitrobenzene

Product 1

HCID 676873474-(6-(2-Methoxyethyloxy)-1H-benzo[d]imidazol-2-yl)-N-(4-morpholinophenyl)benzamide

Procedure

Compound 637 was prepared according to the procedure similar to that described in Scheme III from 1-(2-methoxyethyloxy)-3,4-dinitrobenzene and 4-(4-(4-morpholinophenyl)aminocarbonylbenzaldehyde. [M+H]+ calcd for C27H28N4O4: 473.21; found: 473.08.

Sources & evidence

ORD record
ord-b656b62574454386b2bf4e5a425b085a
Source dataset
uspto-grants-2015_09
Patent number
US09144557B2

Reaction notes

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