4-(6-Indolylaminocarbonyl)benzaldehyde → 4-(6-(3,5-Dimethylisoxazol-4-yl)-1H-benzo[d]imidazol-2-yl)-N-(1H-indol-6-yl)benzamide

HRID 2284281Notes

Reaction equation

HRID 2284281 reaction equation
[CH3:1][C:2]1[C:6]([C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[C:9]([N+:16]([O-])=O)[CH:8]=2)=[C:5]([CH3:19])[O:4][N:3]=1.[NH:20]1[C:28]2[C:23](=[CH:24][CH:25]=[C:26]([NH:29][C:30]([C:32]3[CH:39]=[CH:38][C:35]([CH:36]=O)=[CH:34][CH:33]=3)=[O:31])[CH:27]=2)[CH:22]=[CH:21]1>>[CH3:1][C:2]1[C:6]([C:7]2[CH:12]=[CH:11][C:10]3[N:13]=[C:36]([C:35]4[CH:34]=[CH:33][C:32]([C:30]([NH:29][C:26]5[CH:27]=[C:28]6[C:23]([CH:22]=[CH:21][NH:20]6)=[CH:24][CH:25]=5)=[O:31])=[CH:39][CH:38]=4)[NH:16][C:9]=3[CH:8]=2)=[C:5]([CH3:19])[O:4][N:3]=1

Participants

3

Reactant 2

HCID 866740144-(6-Indolylaminocarbonyl)benzaldehydeHCID 866740151-(3,5-Dimethylisoxazol-4-yl)-3,4-dinitrobenzene

Product 1

HCID 676869804-(6-(3,5-Dimethylisoxazol-4-yl)-1H-benzo[d]imidazol-2-yl)-N-(1H-indol-6-yl)benzamide

Procedure

Compound 651 was prepared according to the procedure similar to that described in Scheme III from 1-(3,5-dimethylisoxazol-4-yl)-3,4-dinitrobenzene and 4-(6-indolylaminocarbonyl)benzaldehyde. [M+H]+ calcd for C27H21N5O2: 448.17; found: 447.97.

Sources & evidence

ORD record
ord-8adb3680277542fdba214d946337caa1
Source dataset
uspto-grants-2015_09
Patent number
US09144557B2

Reaction notes

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